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Infectious Disease: Hepatitis
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Spectrum of diseases/conditions exhibiting hemostatic abnormalities in patients admitted to a medical intensive care unit of a tertiary care hospital
Conclusions: Tropical diseases formed the majority of admissions with bleeding manifestations. Thrombocytopenia is an important marker to predict mortality and also has a significant association with MICU stay. APACHE II score was found to be a good predictor of blood transfusion requirements.
Source: Indian Journal of Critical Care Medicine - October 17, 2018 Category: Intensive Care Authors: Girish Chandrakant Rajadhyaksha Ameena Meah Source Type: research
Thromboelastographic analysis of hemostatic abnormalities in dengue patients admitted in a multidisciplinary intensive care unit: A cross-sectional study
Conclusion: Factor deficiency pattern was the major abnormality noted in dengue patients followed by platelet dysfunction and primary fibrinolysis. Platelet count did not show significant association with platelet function. aPTT did not show significant association with factor deficiency and low fibrinogen patterns. Factor deficiency pattern and low fibrinogen pattern did not show significant association with hepatitis.
Source: Indian Journal of Critical Care Medicine - April 18, 2018 Category: Intensive Care Authors: VK Sureshkumar Deepak Vijayan Shamim Kunhu Zuhail Mohamed Sujith Thomas Muraleedharan Raman Source Type: research
Recent advances in management of acute liver failure
Charles Panackel, Rony Thomas, Benoy Sebastian, Sunil K MathaiIndian Journal of Critical Care Medicine 2015 19(1):27-33Acute liver failure (ALF) is a life-threatening illness, where a previously normal liver fails within days to weeks. Sudden loss of synthetic and detoxification function of liver results in jaundice, encephalopathy, coagulopathy, and multiorgan failure. The etiology of ALF varies demographically. The mortality of ALF is as high as 40-50%. The initial care of patients with ALF depends on prompt recognition of the condition and early detection of etiology. Management includes intensive care support, t...
Source: Indian Journal of Critical Care Medicine - January 6, 2015 Category: Intensive Care Authors: Charles PanackelRony ThomasBenoy SebastianSunil K Mathai Source Type: research
N-acetylcystein in dengue associated severe hepatitis
We report a case of dengue hemorrhagic fever associated severe hepatitis (encephalopathy grade 2-drowsy and intermittent disorientation) treated with NAC resulted in good outcome without hepatic transplantation.
Source: Indian Journal of Critical Care Medicine - March 12, 2014 Category: Intensive Care Authors: Buddhika Widyaratna Peiris HabaragamuwaPalitha Dissanayaka Source Type: research
N-acetylcystein in dengue hepatitis
Viroj WiwanitkitIndian Journal of Critical Care Medicine 2014 18(12):830-830
Source: Indian Journal of Critical Care Medicine - December 5, 2014 Category: Intensive Care Authors: Viroj Wiwanitkit Source Type: research
Strongyloides stercoralis hyperinfection in patient with autoimmune hepatitis and purpura fulminans
We report here a case of Strongyloides stercoralis hyperinfection following immunosuppressive therapy for autoimmune hepatitis and concomitant CMV infection with purpura fulminance and frank sepsis, with fatal outcome.
Source: Indian Journal of Critical Care Medicine - January 11, 2016 Category: Intensive Care Authors: Neha RathorVikas KhillanSK Sarin Source Type: research
Atypical neurological manifestations of chikungunya fever: Two case reports
Subodh Kumar Mahto, Pulin Kumar Gupta, Akanksha Singh, Ramesh Chand MeenaIndian Journal of Critical Care Medicine 2018 22(4):306-308Chikungunya fever (CHIK) is an arboviral disease which is transmitted by a mosquito bite (Aedes aegypti). Fever, polyarthralgia, and maculopapular rash are hallmark clinical manifestations of this disease. These manifestations are self-liming and complete recovery is seen in most of the cases. However, atypical and lethal complications such as myocarditis, hepatitis, Guillain–Barre syndrome (GBS), and meningoencephalitis have been reported in few cases of CHIK. We hereby report tw...
Source: Indian Journal of Critical Care Medicine - April 18, 2018 Category: Intensive Care Authors: Subodh Kumar Mahto Pulin Kumar Gupta Akanksha Singh Ramesh Chand Meena Source Type: research
Hepatitis a virus-induced severe hemolysis complicated by severe Glucose-6-Phosphate Dehydrogenase deficiency
Dhruva Sharma, Omender Singh, Deven Juneja, Amit Goel, Suneel Kumar Garg, Shashank ShekharIndian Journal of Critical Care Medicine 2018 22(9):670-673
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an x-linked recessive genetic disorder with mutation in the G6PD gene. Defect in the enzyme G6PD causes red blood cells (RBCs) to breakdown prematurely causing hemolytic anemia. Hemolytic anemia is also a known hematological complication associated with viral hepatitis. In such patients, hemolysis may be more severe if there is any secondary injury to RBC in the form of membrane defect, oxidative stress, or enzyme defici...
Source: Indian Journal of Critical Care Medicine - September 17, 2018 Category: Intensive Care Authors: Dhruva Sharma Omender Singh Deven Juneja Amit Goel Suneel Kumar Garg Shashank Shekhar Source Type: research
Characteristics, management and outcomes of patients with acute liver failure admitted to Australasian intensive care units.
CONCLUSION: POD is the major cause of ALF in Australian and New Zealand liver transplant centres and is a unique and separate form of ALF. It has a much lower associated mortality and treatment with liver transplantation than non-POD ALF. Non-POD patients have a poor prognosis in the absence of transplantation.
PMID: 31462206 [PubMed - in process]
Source: Critical Care and Resuscitation - August 31, 2019 Category: Intensive Care Tags: Crit Care Resusc Source Type: research
Prevalence and Prognostic Value of Abnormal Liver Test Results in Critically Ill Children and the Impact of Delaying Parenteral Nutrition*
Objectives:
In the Early versus Late Parenteral Nutrition in the Pediatric ICU randomized controlled trial, delaying parenteral nutrition to beyond day 7 (late parenteral nutrition) was clinically superior to supplemental parenteral nutrition initiated within 24 hours (early parenteral nutrition), but resulted in a higher rise in bilirubin. We aimed to document prevalence and prognostic value of abnormal liver tests in the PICU and the impact hereon of withholding early parenteral nutrition.
Design:
Preplanned secondary analysis of the Early versus Late Parenteral Nutrition in the Pediatric ICU randomized controlled t...
Source: Pediatric Critical Care Medicine - December 1, 2018 Category: Pediatrics Tags: Feature Articles Source Type: research
First Human Challenge Testing of a Pneumococcal Vaccine - Double Blind Randomised Controlled Trial.
CONCLUSIONS: PCV reduced pneumococcal colonisation rate, density and duration in healthy adults. The experimental human pneumococcal colonisation model is a safe, cost-effective and efficient method to determine the protective efficacy of new vaccines on pneumococcal colonisation; PCV provides a 'gold standard' against which to test these novel vaccines. Clinical trial registration available at www.isrctn.com, ID 45340436.
PMID: 26114410 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - June 26, 2015 Category: Respiratory Medicine Authors: Collins AM, Wright AD, Mitsi E, Gritzfeld JF, Hancock CA, Pennington SH, Wang D, Morton B, Ferreira DM, Gordon SB Tags: Am J Respir Crit Care Med Source Type: research
Lung Transplantation from Hepatitis C Viremic Donors to Uninfected Recipients.
PMID: 29412687 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - February 7, 2018 Category: Respiratory Medicine Authors: Abdelbasit A, Hirji A, Halloran K, Weinkauf J, Kapasi A, Lien D, Nagendran J, Doucette K Tags: Am J Respir Crit Care Med Source Type: research
Culture Conversion in Patients Treated with Bedaquiline and/or Delamanid: A Prospective Multi-country Study.
We report frequency of sputum culture conversion within six-months of treatment initiation and risk factors for non-conversion. Methods We included patients with a positive baseline culture who initiated a first endTB regimen prior to April 2018. Two consecutive negative cultures collected > 15 days apart constituted culture conversion. We used generalized mixed models to derive marginal predictions for the probability of culture conversion in key subgroups. Findings 1,109 patients initiated a multidrug treatment containing bedaquiline (63%), delamanid (27%) or both (10%). Of these, 939 (85%) experienced culture convers...
Source: American Journal of Respiratory and Critical Care Medicine - July 23, 2020 Category: Respiratory Medicine Authors: Franke MF, Khan P, Hewison C, Khan U, Huerga H, Seung KJ, Rich ML, Zarli K, Samieva N, Oyewusi L, Nair P, Mudassar M, Melikyan N, Lenggogeni P, Lecca L, Kumsa A, Khan M, Islam S, Hussein K, Docteur W, Chumburidze N, Berikova E, Atshemyan H, Atwood S, Alam Tags: Am J Respir Crit Care Med Source Type: research
Sovaldi - a "Revolution" in Clinical Care, or in Marketing and Public Relations?
DiscussionWashington Post/ Kaiser Health NewsOn May 12, 2014, in an article on the dilemma the drug's US price of $1000/ pill presents to Medicare, Richard Knox wrote this about a patient with the infection:Previous drug treatments didn't clear the virus from Bianco's system. But it's almost certain that potent new drugs for hep-C could cure him. In other words, the article asserted that Sovaldi and similar drugs cure nearly everyone with hepatitis C, even those not cured by previous treatment. ReutersOn May 20, 2014, in an article about how US health insurers are balking at the price of Sovaldi, was this statement b...
Source: Health Care Renewal - May 28, 2014 Category: Health Management Tags: evidence-based medicine Gilead health care prices manipulating clinical research Sovaldi You heard it here first Source Type: blogs
Decompensated liver cirrhosis
Publication date: Available online 3 March 2015 Source:Anaesthesia & Intensive Care Medicine Author(s): Tom G. Bird , Prakash Ramachandran , Euan Thomson The incidence of liver disease continues to increase and is now one of the leading causes of death in the United Kingdom. The increasing prevalence of viral hepatitis combined with a surge in the incidence of both alcohol and obesity related liver disease mean that critical care units are increasingly being called upon to assist in managing those with life-threatening complications of end-stage liver disease. Decompensated cirrhosis is not a single organ illness...
Source: Anaesthesia and intensive care medicine - March 3, 2015 Category: Anesthesiology Source Type: research
